What I find interesting is that book sales are actually on the rise, as are e-book sales. Some market research I read a while ago said people will often buy both a printed book and an e-book, using the e-book while travelling/commuting/etc. and keeping the printed book at home.
I never bought from Borders in the UK. I buy my academic/history/classics books from the OUP store at Oxford or Heffers in cambridge, other things I buy from whatever independent store in London I happen to be near. Usually Foyles. Only things like the Mass Effect books I get from amazon.